Guanylate Cyclase Activator

Guanylate Cyclase Activators (33):

Cat. No.	Product Name	Effect	Purity

HY-14927

Lificiguat	Activator	99.74%
Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with K_d of 0.6-1.1 μM in the presence of CO.

HY-16774

Vericiguat	Activator	99.27%
Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

HY-14779

Riociguat	Activator	99.58%
Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-P5077A

Guanylin (mouse, rat) (TFA)	Activator
Guanylin (mouse, rat) TFA, a petide, is composed of 15 amino acids. Guanylin (mouse, rat) TFA is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) TFA can be used for the research of diarrhea.

HY-14181

Cinaciguat	Activator	99.73%
Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

HY-113926

BAY 60-2770	Activator	98.97%
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.

HY-12376

BAY 41-2272	Activator	99.93%
BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research.

HY-109136

Runcaciguat	Activator	99.42%
Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.

HY-109039

Praliciguat	Activator	99.77%
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC₅₀ of 197 nM.

HY-17500

Ataciguat	Activator	99.40%
Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.

HY-109066

Olinciguat	Activator	98.44%
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

HY-P1179A

Guanylin(human) TFA	Activator
Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-14181A

Cinaciguat hydrochloride	Activator	98.90%
Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC₅₀ of 15 nM in platelets.

HY-78237

Nelociguat	Activator	99.73%
Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.

HY-W062836

BAY 41-8543	Activator	99.94%
BAY 41-8543 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research.

HY-153369

BAY-747	Activator
BAY-747 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model.

HY-117917

(Rac)-MGV354	Activator	99.66%
(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC₅₀s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.

HY-107546

CFM 1571 hydrochloride	Activator	99.47%
CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC₅₀ and IC₅₀ of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.

HY-P1179

Guanylin(human)	Activator
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

HY-137446

Mosliciguat	Activator
Mosliciguat is a guanylate cyclase activator.

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